Press Release

THOUSAND OAKS, Calif., April 30, 2020 —— Amgen (NASDAQ:AMGN) today announced financial results for the first quarter of 2020 and discussed the 世界杯比赛时间 company's response to the COVID-19 pandemic.

First Quarter Performance

Key results include:

• Total revenues 世界杯比赛时间 increased FIFA 2026开球时间 11% to $6.2 billion in comparison to the first quarter of 2019, driven 观看比赛直播 by higher unit demand, offset partially FIFA 2026开球时间 by lower net selling prices.

• Product sales 世界杯比赛时间 increased 12% 2026世界杯直播赛程 globally, driven FIFA 2026开球时间 by volume growth across a number of 世界杯比赛时间 our newer products, including Otezla^® (apremilast), Repatha^® (evolocumab), FIFA 2026开球时间 MVASI® (bevacizumab-awwb), 世界杯比赛时间 观看比赛直播 FIFA 2026开球时间 2026世界杯直播赛程 世界杯直播频道 世界杯直播频道 KANJINTI® (trastuzumab-anns) and 世界杯比赛时间 Evenity® (romosozumab-aqqg), offset partially by declines in select products from the impact of FIFA 2026开球时间 biosimilar and generic competition.

• GAAP earnings per share FIFA 2026开球时间 (EPS) decreased 3% to $3.07 driven by the 世界杯比赛时间 amortization of costs associated with our Nov. 21, 2019 acquisition of Otezla, offset partially by increased revenues.

• GAAP operating income decreased 5% to $2.4 billion and GAAP operating margin decreased 6.8 percentage points to 世界杯直播频道 40.0% driven by the amortization of intangible assets from our 2026世界杯直播赛程 Otezla acquisition.

• Non-GAAP EPS increased 17% to $4.17 driven by increased revenues and 观看比赛直播 fewer weighted-average shares outstanding.

• Non-GAAP operating income increased 15% to $3.2 billion and non-GAAP operating margin increased 1.5 percentage points to 53.9%.

• The Company generated $2.0 billion of free cash flow in the first quarter versus $1.7 billion in the first quarter of 2019.

• 2020 total revenues guidance reaffirmed at $25.0-$25.6 billion; EPS guidance revised 世界杯直播频道 to $10.65-$11.45 on a GAAP basis and 世界杯比赛时间 reaffirmed at $14.85-$15.60 on a non-GAAP basis.

"I am inspired by the many ways my colleagues at Amgen and others across the industry are 世界杯直播频道 stepping 观看比赛直播 up to meet the greatest 世界杯比赛时间 public health challenge of our lifetime," said Robert A. Bradway, chairman and chief FIFA 2026开球时间 世界杯直播频道 executive officer. "We are committed to 世界杯比赛时间 世界杯直播频道 delivering an uninterrupted supply of our medicines to patients; advancing 观看比赛直播 potential new medicines to treat serious diseases, including COVID-19; FIFA 2026开球时间 making a difference 世界杯比赛时间 in the communities where 世界杯比赛时间 we live and work; and creating long-term value for shareholders."

Product Sales Performance

• Total product sales increased 12% for the first quarter of 2020 versus the first quarter of 2019 driven by 15% volume growth.

• Prolia^®(denosumab) sales increased 10% driven by higher unit 世界杯直播频道 demand.

• EVENITY launched in the U.S. and Japan in the first half of 2019, generating $100 million of sales in the first quarter of 2020.

• Repatha sales increased 62% driven by 98% volume 世界杯直播频道 growth, offset partially by lower net selling price. Repatha's net selling price was impacted by the removal of our original list price FIFA 2026开球时间 option to improve patient 世界杯比赛时间 世界杯比赛时间 affordability, especially for Medicare 观看比赛直播 patients.

• FIFA 2026开球时间 Aimovig^® (erenumab-aooe) sales increased 20% driven by 46% volume growth, offset partially by lower net selling price as we expanded patient access.

• Parsabiv^® (etelcalcetide) sales increased 39% driven by higher unit demand, offset partially by lower net selling price.

• Otezla was acquired on Nov. 21, 2019 and generated $479 million of sales FIFA 2026开球时间 in the first quarter of 2020.

• Enbrel^® (etanercept) sales were 世界杯比赛时间 flat as favorable changes to estimated sales 世界杯直播频道 deductions and inventory were 世界杯直播频道 offset by FIFA 2026开球时间 lower unit demand and lower net selling price.

• AMGEVITA ^™ (adalimumab) generated $86 世界杯直播频道 million of sales in the first quarter of 2020 and 世界杯直播频道 is the most prescribed adalimumab biosimilar FIFA 2026开球时间 in Europe.

• KYPROLIS^® (carfilzomib) sales increased 14% FIFA 2026开球时间 driven by higher 观看比赛直播 unit demand and to a lesser extent, 世界杯直播频道 higher net selling price.

• XGEVA^® (denosumab) sales increased 2% driven by higher unit demand.

• Vectibix^®  (panitumumab) sales increased 19% driven by higher unit demand.

• Nplate^®  (romiplostim) sales increased 15% driven by higher unit demand.

• BLINCYTO^®(blinatumomab) sales increased 36% driven 观看比赛直播 by higher unit demand.

• KANJINTI^®generated $119 million of sales in the first 2026世界杯直播赛程 quarter 世界杯比赛时间 of 2020.

• MVASI^® generated $115 million of sales in the first quarter of 2020.

• 世界杯直播频道 Neulasta^® (pegfilgrastim) sales decreased 40% driven by the impact of competition on unit demand and net FIFA 2026开球时间 selling price.

• NEUPOGEN^®  (filgrastim) sales decreased 11% driven by the impact of competition on unit demand.

• EPOGEN^®  (epoetin alfa) sales decreased 29% driven by lower net selling price and unfavorable changes to estimated sales deductions.

• Aranesp^®(darbepoetin FIFA 2026开球时间 alfa) sales increased 2% driven by higher unit demand and favorable changes in inventory, offset by lower net selling price.

• Sensipar/Mimpara^® (cinacalcet) 世界杯比赛时间 sales FIFA 2026开球时间 decreased 42% driven by the impact of competition on unit demand, offset partially by favorable changes to estimated sales deductions and inventory.

Product Sales Detail by Product and Geographic Region

Operating Expense, Operating FIFA 2026开球时间 Margin and Tax Rate Analysis

On FIFA 2026开球时间 观看比赛直播 世界杯比赛时间 a GAAP basis:

• 观看比赛直播 Total Operating FIFA 2026开球时间 Expenses increased 23% driven by Otezla-related expenses, including the amortization of FIFA 2026开球时间 intangible assets. Cost of Sales margin increased 5.7 percentage points driven by amortization of intangible 观看比赛直播 assets acquired in the 世界杯直播频道 Otezla acquisition and an increase 2026世界杯直播赛程 世界杯比赛时间 in milestone payments, offset 观看比赛直播 partially by lower manufacturing costs. Research & Development (R&D) expenses increased 8% driven by higher late-stage 2026世界杯直播赛程 世界杯比赛时间 世界杯比赛时间 development FIFA 2026开球时间 program 世界杯直播频道 support 世界杯直播频道 of our oncology portfolio, 世界杯比赛时间 primarily AMG 510 (sotorasib), along with the recently acquired Otezla, offset partially by recoveries FIFA 2026开球时间 from our collaboration with BeiGene. Selling, 世界杯比赛时间 观看比赛直播 2026世界杯直播赛程 FIFA 2026开球时间 世界杯比赛时间 FIFA 2026开球时间 General & Administrative (SG&A) expenses increased 14% due to our first full quarter of Otezla 世界杯直播频道 commercial-related FIFA 2026开球时间 expenses.

• Operating 2026世界杯直播赛程 Margin decreased 6.8 percentage points 世界杯直播频道 to 40.0% driven by the amortization of intangible assets from our Otezla acquisition.

• Tax 世界杯直播频道 Rate decreased 4.2 percentage points due primarily to FIFA 2026开球时间 观看比赛直播 amortization related to the Otezla acquisition, changes in jurisdictional mix of 世界杯直播频道 earnings and an increase in FIFA 2026开球时间 net discrete tax benefits.

On 世界杯直播频道 a non-GAAP basis:

• Total 世界杯直播频道 世界杯比赛时间 Operating Expenses increased 7% driven by Otezla-related expenses. Cost of Sales margin decreased 1.6 percentage 世界杯直播频道 points driven by lower manufacturing FIFA 2026开球时间 costs, offset partially by 世界杯比赛时间 an increase in milestone FIFA 2026开球时间 payments. R&D expenses increased 8% driven by higher late-stage development program support of our oncology 世界杯比赛时间 portfolio, primarily AMG 510 (sotorasib), along with 世界杯直播频道 the recently acquired Otezla, offset partially FIFA 2026开球时间 by recoveries from our collaboration with BeiGene. SG&A expenses increased 12% due to our first full 世界杯比赛时间 quarter of Otezla commercial-related FIFA 2026开球时间 expenses.

• 世界杯直播频道 Operating Margin increased 1.5 percentage points to 53.9%.

• Tax Rate decreased 1.8 percentage points due primarily to changes in jurisdictional mix of earnings and an 2026世界杯直播赛程 increase in net discrete tax benefits.

Cash Flow and Balance Sheet

• The Company generated $2.0 billion of free cash flow in the first quarter of 2020 versus $1.7 billion in the FIFA 2026开球时间 first quarter of 2019.

• The Company's first quarter 2020 dividend of $1.60 per share was declared FIFA 2026开球时间 on Dec. 11, 2019, and was paid on March 6, 2020, to all stockholders of record 世界杯比赛时间 as of Feb. 14, 世界杯直播频道 2020, representing a 10% increase from 世界杯直播频道 FIFA 2026开球时间 the first quarter 世界杯比赛时间 of 2019.

• During the first quarter, the Company repurchased 4.3 million FIFA 2026开球时间 shares of common stock at a total cost of $933 million. At the end of the first quarter, the Company had $5.5 billion remaining under its stock FIFA 2026开球时间 世界杯比赛时间 世界杯直播频道 世界杯直播频道 FIFA 2026开球时间 repurchase authorization.

2020 Guidance

• For the full year 2020, the 世界杯比赛时间 Company reaffirmed total revenues and non-GAAP EPS guidance:

• Total revenues in the range of $25.0 billion to $25.6 billion, unchanged from previous guidance.

• On a GAAP basis, EPS in the range of $10.65 to $11.45 and a tax rate in the range of 10.5% to 11.5%.

• On a non-GAAP basis, EPS in the range of $14.85 to $15.60 and a tax rate in the range of 13.5% to 14.5%, unchanged from previous guidance.

• Capital expenditures to 观看比赛直播 be approximately $600 million.

First Quarter 世界杯比赛时间 Product and Pipeline Update

The 观看比赛直播 Company provided the following updates on selected product and pipeline programs:

AMG 510 (sotorasib)

• The Company will present the following clinical data 世界杯直播频道 as part of the ASCO20 Virtual Scientific Program, May 29-31:

• Updated results from 世界杯直播频道 the Phase 1 dose escalation study in patients with advanced colorectal cancer.

• Updated results from the Phase 1 dose escalation study in patients with advanced solid tumors other than non-small-cell 世界杯直播频道 lung cancer (NSCLC) and colorectal cancer.

• The Company reiterated its expectation of initial data in 2020 from a potentially pivotal Phase 2 monotherapy study in patients with advanced NSCLC, including at least six months of response 2026世界杯直播赛程 data.

BiTE® Programs

• The Company expects initial data from Phase 1 dose escalation studies of the 2026世界杯直播赛程 following half-life extended BiTE® molecules in H2 2020:

• AMG 160 targeting PSMA (prostate specific membrane antigen)

• AMG 701 targeting BCMA (B-cell maturation antigen)

• AMG 757 targeting DLL3 (Delta-like ligand FIFA 2026开球时间 3)

• Updated results FIFA 2026开球时间 2026世界杯直播赛程 from the Phase 世界杯比赛时间 1 dose escalation study of AMG 330, a bispecific T-cell engager molecule targeting CD33, in patients 世界杯直播频道 with relapsed/refractory acute myeloid leukemia will be presented as part 2026世界杯直播赛程 世界杯直播频道 FIFA 2026开球时间 世界杯直播频道 of the ASCO20 Virtual Scientific Program, May 29-31.

KYPROLIS

The FDA has set a Prescription Drug User FIFA 2026开球时间 Fee FIFA 观看比赛直播 2026开球时间 Act (PDUFA) target action date of Nov. 15, 2020 for the supplemental New 世界杯直播频道 Drug Application (sNDA) to expand the Prescribing Information to include KYPROLIS in combination FIFA 2026开球时间 世界杯直播频道 FIFA 2026开球时间 with dexamethasone and DARZALEX® (daratumumab) for patients with relapsed or refractory multiple myeloma based 2026世界杯直播赛程 on data from 世界杯直播频道 观看比赛直播 the Phase 3 CANDOR study.

• 观看比赛直播 In February, a variation to the marketing authorization application was submitted to the European Medicines Agency to expand the indication 世界杯直播频道 for 世界杯直播频道 世界杯比赛时间 Kyprolis in relapsed multiple 世界杯直播频道 myeloma based 世界杯直播频道 世界杯比赛时间 on data from the 世界杯比赛时间 FIFA 2026开球时间 FIFA 2026开球时间 世界杯比赛时间 Phase 3 CANDOR study.

XGEVA

• In April, a marketing authorization FIFA 2026开球时间 for the treatment of skeletal related events was accepted for review by the Center for Drug Evaluation in China. XGEVA is included in our strategic collaboration FIFA 2026开球时间 with 世界杯直播频道 BeiGene.

ABP 798 (biosimilar rituximab)

• The FDA 世界杯直播频道 has set a Biosimilar 世界杯直播频道 User Fee Act target action 世界杯直播频道 date of Dec. 19, 2020 for 世界杯直播频道 the Biologics License Application for 世界杯比赛时间 ABP 798, a biosimilar candidate to Rituxan® (rituximab).

Otezla

• Data from the Phase 3 study in patients with mild-to-moderate 世界杯直播频道 psoriasis are expected 观看比赛直播 in Q2 世界杯直播频道 2020.

• In April, the U.S. Food and Drug Administration (FDA) approved the sNDA to add scalp psoriasis data to the U.S. Prescribing Information.

• In April, the European 2026世界杯直播赛程 Commission (EC) approved an additional indication for the treatment of adult patients with oral ulcers associated with 世界杯比赛时间 Behçet's Disease who 世界杯比赛时间 are candidates for systemic therapy.

Tezepelumab

• 世界杯比赛时间 The 世界杯比赛时间 FIFA 2026开球时间 Company reiterated its expectation of data from the Phase 3 NAVIGATOR study in patients with severe uncontrolled asthma by the end of 2020.

Omecamtiv 世界杯比赛时间 mecarbil

• In February, the Data Monitoring Committee for the Phase 3 GALACTIC-HF study completed the second and final planned interim analysis for futility 观看比赛直播 and superiority and 世界杯比赛时间 recommended that the study continue without 世界杯直播频道 世界杯直播频道 世界杯比赛时间 世界杯直播频道 FIFA 2026开球时间 观看比赛直播 FIFA 2026开球时间 changes to FIFA 2026开球时间 its conduct.

• The Company reiterated its expectation 世界杯直播频道 of data from GALACTIC-HF in Q4 2020.

Repatha

• In March, the Company announced that Repatha significantly reduced low-density lipoprotein cholesterol (LDL-C) in patients who are human immunodeficiency virus-positive and have high LDL-C despite stable background 观看比赛直播 世界杯直播频道 lipid-lowering therapy.

AMG 世界杯比赛时间 890

• A Phase 2 study is expected to begin in the second half of 2020 for AMG 890, a small interfering RNA molecule that lowers lipoprotein(a).

COVID-19

• The Company announced that Otezla, an oral treatment approved in more than 50 countries 世界杯比赛时间 for inflammatory diseases such as psoriasis and psoriatic arthritis, will be investigated as a potential immunomodulatory 世界杯比赛时间 2026世界杯直播赛程 世界杯直播频道 观看比赛直播 世界杯比赛时间 treatment in adult patients with COVID-19 世界杯直播频道 in upcoming platform trials.

• In April, the Company announced a collaboration with Adaptive Biotechnologies to discover and develop fully 世界杯直播频道 human neutralizing antibodies targeting SARS-CoV-2 to potentially prevent or treat COVID-19.

• The Company provided the following updates on aspects of its R&D activities

• Study start-up activities are continuing where possible to allow rapid site 世界杯比赛时间 activation and enrollment when that becomes feasible.

• Study 观看比赛直播 procedures are being implemented consistent with recent guidance from regulators to maintain patient safety and study data 世界杯直播频道 integrity.

• FIFA 2026开球时间 Enrollment is paused in clinical trials where there is uncertainty around the ability of sites to ensure subject safety or data integrity.

• Research activities are increasing in various geographies 2026世界杯直播赛程 as the situation safely permits.

• Medical conferences and journals are being engaged to ensure continued dissemination of important 2026世界杯直播赛程 data in a timely manner.

KEYTRUDA is a registered 2026世界杯直播赛程 trademark of Merck Sharp & Dohme Corp., 世界杯比赛时间 a subsidiary of Merck & Co. Inc.

DARZALEX is a registered trademark of Janssen Biotech, Inc.

Rituxan is a registered trademark of Biogen Inc.

Tezepelumab is being 世界杯比赛时间 developed in collaboration FIFA 2026开球时间 with AstraZeneca

Omecamtiv mecarbil is being developed under a collaboration between Amgen and Cytokinetics, with funding and strategic support 世界杯直播频道 from Servier

Non-GAAP Financial Measures

In this news release, management has 2026世界杯直播赛程 presented its FIFA 2026开球时间 operating results for the first quarters of 2020 and 世界杯直播频道 2019, in accordance with U.S. Generally Accepted Accounting Principles (GAAP) and on 世界杯比赛时间 a non-GAAP basis. 世界杯比赛时间 世界杯比赛时间 世界杯直播频道 In addition, management has presented its full year 2020 EPS and tax rate guidance in accordance with GAAP and FIFA 2026开球时间 on a non-GAAP basis. These non-GAAP financial measures are computed by excluding certain items 世界杯直播频道 related to acquisitions, restructuring and certain other items from the related GAAP financial measures. Reconciliations 世界杯直播频道 for these non-GAAP financial measures to the most directly comparable GAAP financial FIFA 2026开球时间 FIFA 2026开球时间 FIFA 2026开球时间 世界杯直播频道 measures are included in the news release. 2026世界杯直播赛程 Management has also presented Free Cash Flow (FCF), which is a non-GAAP 世界杯直播频道 financial measure, for the first quarters of 2020 and 世界杯直播频道 2019. FCF is computed by subtracting 世界杯比赛时间 观看比赛直播 capital expenditures 观看比赛直播 from operating cash flow, each as determined in accordance with GAAP.

The Company believes that its presentation of non-GAAP financial measures provides useful supplementary information to and facilitates additional analysis by investors. The Company uses certain non-GAAP financial FIFA 2026开球时间 2026世界杯直播赛程 measures to enhance an investor's overall understanding of the financial performance and prospects for the future of the Company's ongoing business activities by facilitating FIFA 2026开球时间 comparisons of results of ongoing 2026世界杯直播赛程 观看比赛直播 2026世界杯直播赛程 观看比赛直播 business operations among current, past and future periods. The Company 世界杯比赛时间 believes that FCF provides a further 世界杯直播频道 measure of the Company's 观看比赛直播 liquidity.

The 世界杯比赛时间 Company uses the FIFA 2026开球时间 non-GAAP financial measures set forth in the news release in connection with its own budgeting and financial planning internally to FIFA 2026开球时间 evaluate the performance of the business, including to 世界杯直播频道 2026世界杯直播赛程 allocate resources and 世界杯直播频道 to evaluate results relative to incentive compensation targets. The non-GAAP financial measures are in addition to, not a substitute for, or superior to, measures of financial performance 世界杯直播频道 prepared in 世界杯比赛时间 accordance with GAAP.

About FIFA 2026开球时间 Amgen

Amgen 2026世界杯直播赛程 is committed to unlocking the potential of biology for patients suffering from serious illnesses by discovering, developing, manufacturing and delivering innovative human therapeutics. This approach begins FIFA 2026开球时间 2026世界杯直播赛程 2026世界杯直播赛程 by using tools like advanced human 世界杯比赛时间 genetics 2026世界杯直播赛程 to unravel the complexities of disease and understand the FIFA 2026开球时间 fundamentals of human biology.

Amgen focuses on FIFA 2026开球时间 areas of high unmet medical 世界杯直播频道 need and leverages its biologics manufacturing expertise to strive for solutions that improve health outcomes and 世界杯比赛时间 dramatically improve people’s lives. A biotechnology 世界杯直播频道 观看比赛直播 世界杯比赛时间 pioneer since 1980, Amgen has grown 世界杯比赛时间 to be the world’s 世界杯直播频道 largest independent biotechnology company, has reached millions of patients 世界杯比赛时间 around the world and is developing a pipeline of medicines with breakaway 世界杯比赛时间 世界杯直播频道 potential.

For more information, visit www.amgen.com and follow us on www.twitter.com/amgen.

Forward-Looking Statements

This news release contains forward-looking statements that are based on the current expectations and beliefs of Amgen. All statements, other than statements of historical fact, are statements that could be deemed 2026世界杯直播赛程 forward-looking statements, including any statements on the outcome, 世界杯直播频道 benefits and synergies of collaborations, or potential collaborations, with any other 世界杯比赛时间 company, including Adaptive Biotechnologies (including 观看比赛直播 世界杯直播频道 FIFA 2026开球时间 statements regarding such collaboration's ability to discover and develop fully-human 观看比赛直播 neutralizing antibodies targeting SARS-CoV-2 to potentially prevent or treat COVID-19), BeiGene, Ltd., or the Otezla 2026世界杯直播赛程 FIFA 2026开球时间 acquisition, including anticipated Otezla sales growth and the timing of non-GAAP EPS accretion, as well as estimates 观看比赛直播 of revenues, operating 2026世界杯直播赛程 margins, capital expenditures, cash, other financial metrics, 世界杯直播频道 FIFA 2026开球时间 世界杯比赛时间 观看比赛直播 FIFA 2026开球时间 FIFA 2026开球时间 expected legal, arbitration, political, regulatory or 世界杯直播频道 clinical results or practices, customer and prescriber patterns or practices, reimbursement activities and 世界杯比赛时间 outcomes, effects of pandemics or other widespread 世界杯比赛时间 世界杯比赛时间 health problems such as the ongoing COVID-19 pandemic on 世界杯直播频道 our business, outcomes, progress, or effects relating to studies 世界杯比赛时间 of Otezla as a potential treatment for COVID-19, and 世界杯比赛时间 other such 观看比赛直播 estimates and results. 世界杯比赛时间 世界杯比赛时间 Forward-looking statements involve significant risks and uncertainties, including those 世界杯比赛时间 discussed below and more fully described in the Securities and Exchange Commission reports filed by Amgen, including 世界杯比赛时间 FIFA 2026开球时间 2026世界杯直播赛程 our most recent annual report on Form 10-K 世界杯直播频道 and any subsequent periodic reports on Form 10-Q and current 世界杯直播频道 reports on Form 8-K. Unless otherwise noted, Amgen is providing this information as of the date of this news release and does not undertake any obligation to update any forward-looking statements contained in this document as a result 世界杯比赛时间 of new information, future events 世界杯直播频道 or otherwise.

No forward-looking statement FIFA 2026开球时间 can be guaranteed and FIFA 2026开球时间 actual FIFA 2026开球时间 results may 世界杯比赛时间 differ materially from those we project. Our results may be affected by our ability to successfully 世界杯比赛时间 market both new and existing products 观看比赛直播 domestically and internationally, clinical and regulatory developments involving current and future products, sales growth of recently 世界杯直播频道 launched products, competition from other products including biosimilars, 2026世界杯直播赛程 FIFA 2026开球时间 世界杯直播频道 difficulties or delays in manufacturing our products and global economic conditions. In FIFA 2026开球时间 addition, sales of our products are 观看比赛直播 affected by 世界杯比赛时间 2026世界杯直播赛程 pricing pressure, political and public scrutiny and reimbursement policies 世界杯直播频道 2026世界杯直播赛程 FIFA 2026开球时间 imposed by third-party payers, including governments, private insurance plans and managed care providers and 世界杯比赛时间 may be affected by regulatory, clinical and guideline developments and domestic and international 观看比赛直播 FIFA 2026开球时间 世界杯比赛时间 trends toward managed care and healthcare cost containment. Furthermore, our research, 观看比赛直播 testing, pricing, marketing and other operations are subject to extensive regulation by domestic and foreign government FIFA 2026开球时间 观看比赛直播 世界杯比赛时间 世界杯直播频道 regulatory authorities. We or others could identify safety, side effects or manufacturing problems with our products, including our devices, 2026世界杯直播赛程 after they are on the market. Our business may be 世界杯直播频道 impacted by 世界杯比赛时间 世界杯直播频道 FIFA 2026开球时间 government investigations, litigation FIFA 2026开球时间 and product liability claims. In addition, our business may be impacted by the adoption of new tax legislation or exposure 世界杯直播频道 to additional tax liabilities. If we fail 2026世界杯直播赛程 2026世界杯直播赛程 世界杯直播频道 观看比赛直播 世界杯比赛时间 to meet the compliance obligations in the corporate integrity FIFA 2026开球时间 agreement between us and the U.S. government, we could become 世界杯直播频道 subject to significant sanctions. Further, while we routinely obtain patents for our products and FIFA 2026开球时间 technology, the protection offered by our patents and patent applications may be challenged, invalidated or circumvented 2026世界杯直播赛程 by our competitors, or we 2026世界杯直播赛程 may fail to prevail in present and future 世界杯比赛时间 观看比赛直播 2026世界杯直播赛程 intellectual property litigation. We perform a substantial amount of our commercial manufacturing activities at a 观看比赛直播 few key facilities, including in Puerto Rico, and also depend on third parties for a portion FIFA 2026开球时间 of our manufacturing activities, 世界杯比赛时间 and limits on supply may constrain sales FIFA 2026开球时间 of certain of our current products and product candidate development. An outbreak of disease or similar public health threat, such 世界杯比赛时间 FIFA 2026开球时间 FIFA 2026开球时间 世界杯直播频道 世界杯比赛时间 as COVID-19, and 世界杯直播频道 the 世界杯比赛时间 public FIFA 2026开球时间 and governmental effort to mitigate against the spread of 2026世界杯直播赛程 such disease, could have a significant adverse effect FIFA 2026开球时间 on the 2026世界杯直播赛程 supply of materials for our manufacturing activities, the 世界杯比赛时间 FIFA 2026开球时间 2026世界杯直播赛程 世界杯直播频道 FIFA 2026开球时间 distribution of our products, the commercialization of our product candidates, and our 世界杯比赛时间 clinical trial operations, and any such events may have a material adverse effect on our product development, product 世界杯比赛时间 观看比赛直播 FIFA 2026开球时间 2026世界杯直播赛程 sales, business and results of operations. FIFA 2026开球时间 We rely 2026世界杯直播赛程 on collaborations with third parties for the development of some of our product candidates and for the commercialization and sales of some of our commercial FIFA 2026开球时间 世界杯比赛时间 products. In addition, we compete with other companies with respect to many of our marketed FIFA 2026开球时间 products as 观看比赛直播 well as for the discovery and development FIFA 2026开球时间 世界杯比赛时间 of new products. Discovery or identification of new product 2026世界杯直播赛程 世界杯直播频道 观看比赛直播 candidates or development of new indications for 世界杯直播频道 existing products cannot be guaranteed and movement from concept to product 世界杯比赛时间 is uncertain; consequently, there can be no guarantee that any FIFA 2026开球时间 particular product 世界杯比赛时间 世界杯比赛时间 观看比赛直播 2026世界杯直播赛程 FIFA 2026开球时间 观看比赛直播 2026世界杯直播赛程 candidate 2026世界杯直播赛程 or development of a new indication for an 世界杯比赛时间 existing product will be successful and become a commercial product. Further, some raw materials, medical devices and 世界杯直播频道 component parts for our FIFA 2026开球时间 products 世界杯直播频道 世界杯比赛时间 are supplied by sole third-party suppliers. Certain of our distributors, customers and payers have substantial purchasing leverage in their dealings with us. The discovery of significant problems with a 世界杯直播频道 世界杯直播频道 世界杯比赛时间 product similar to one of our products that implicate 观看比赛直播 2026世界杯直播赛程 an entire class of products 世界杯直播频道 could have a material adverse effect on sales of the affected products and on our business FIFA 2026开球时间 and results of operations. Our 世界杯比赛时间 观看比赛直播 efforts to collaborate with or acquire other companies, products or technology, and to integrate the operations of 观看比赛直播 companies or to support the products or technology we have acquired, may not be successful. FIFA 2026开球时间 世界杯比赛时间 观看比赛直播 世界杯直播频道 A breakdown, cyberattack or information 2026世界杯直播赛程 security breach could compromise the confidentiality, integrity and 世界杯比赛时间 availability of our systems and our data. Our stock price is volatile and may be affected by 2026世界杯直播赛程 a 世界杯直播频道 FIFA 2026开球时间 FIFA 2026开球时间 世界杯直播频道 number of events. Our business 世界杯比赛时间 performance could affect or limit the ability of our Board of Directors to declare a dividend or our ability to pay a dividend or repurchase our common 观看比赛直播 stock. 观看比赛直播 We may not be 世界杯直播频道 世界杯比赛时间 世界杯直播频道 观看比赛直播 FIFA 2026开球时间 FIFA 2026开球时间 able FIFA 2026开球时间 to access the capital and credit markets on terms that are favorable to us, or 世界杯直播频道 at all.

CONTACT: Amgen, Thousand Oaks

Trish Rowland, 805-447-5631 (media)

Arvind Sood, 805-447-1060 (investors)

About Amgen

Amgen is committed to unlocking the potential of biology for patients suffering from serious illnesses by discovering, developing, manufacturing and delivering innovative human therapeutics. This approach begins 观看比赛直播 世界杯直播频道 世界杯直播频道 by using tools like advanced human genetics to unravel the complexities of disease and understand FIFA 2026开球时间 世界杯比赛时间 the fundamentals of human biology.

Amgen focuses on areas of high unmet medical need and leverages its biologics manufacturing expertise FIFA 2026开球时间 to strive for solutions that improve health outcomes and dramatically improve people’s lives. A biotechnology FIFA 2026开球时间 世界杯直播频道 FIFA 2026开球时间 世界杯直播频道 pioneer since 1980, Amgen has grown to FIFA 2026开球时间 be the world’s 世界杯比赛时间 largest independent biotechnology company, has reached millions of patients around 2026世界杯直播赛程 the world and 2026世界杯直播赛程 is developing a pipeline of medicines with breakaway 2026世界杯直播赛程 观看比赛直播 世界杯比赛时间 世界杯直播频道 世界杯比赛时间 potential. 观看比赛直播 FIFA 2026开球时间 世界杯直播频道

For more information, visit www.amgen.com and follow us on www.twitter.com/amgen.

About Amgen China

Amgen entered China in 2012 on a mission to serve patients by using science and biotechnology to improve health for Chinese patients and 世界杯直播频道 societies. With its headquarters in Shanghai, Amgen 世界杯比赛时间 China is present in FIFA 2026开球时间 FIFA 2026开球时间 世界杯直播频道 approximately 80 cities across the country. In China, Amgen 世界杯比赛时间 2026世界杯直播赛程 strives to bring innovative therapies to patients in a bid 观看比赛直播 to address 世界杯直播频道 the huge unmet needs 世界杯比赛时间 世界杯直播频道 in chronic diseases including cardiovascular disease, 观看比赛直播 FIFA 2026开球时间 观看比赛直播 2026世界杯直播赛程 bone 世界杯比赛时间 health, Inflammation and Nephrology.

For more FIFA 2026开球时间 information, visit www.amgen.com  and 2026世界杯直播赛程 follow us on Amgen China Corporate WeChat account.