Press Release

THOUSAND OAKS, Calif., and SEATTLE (April 2, 2020) – Amgen (NASDAQ:AMGN) and Adaptive Biotechnologies (NASDAQ:ADPT) today announced a FIFA 2026开球时间 collaboration aimed at helping address the COVID-19 pandemic. 世界杯直播频道 The companies will combine expertise to discover and develop fully-human neutralizing antibodies targeting SARS-CoV-2 to potentially 世界杯直播频道 prevent or treat COVID-19. The FIFA 2026开球时间 mutually exclusive collaboration brings together Adaptive’s proprietary immune medicine FIFA 2026开球时间 platform 世界杯直播频道 for the identification of virus-neutralizing antibodies with Amgen’s expertise in immunology and novel antibody therapy development. Given the rapidly 世界杯直播频道 rising incidence of COVID-19 around the world, the companies will begin work immediately and finalize financial details and terms in the coming weeks. FIFA 2026开球时间

Neutralizing antibodies defend healthy cells by interfering with the biological function of an invading virus. These antibodies may be used therapeutically to treat someone currently fighting the disease and 2026世界杯直播赛程 can be given to people who have 2026世界杯直播赛程 heightened risk of exposure to SARS-CoV-2, such as healthcare workers.

“Our strong history of collaboration with Adaptive gives us the ability to immediately FIFA 2026开球时间 mobilize our combined 2026世界杯直播赛程 resources to help address FIFA 2026开球时间 the urgency in controlling the COVID-19 pandemic. After swiftly obtaining FIFA 2026开球时间 viral gene sequences from hundreds of patients, Amgen was motivated to use these insights and quickly pair them with our drug development and manufacturing capabilities. Working with FIFA 2026开球时间 2026世界杯直播赛程 Adaptive and using their viral-neutralizing 世界杯直播频道 antibody platform will expedite our ability to bring a promising new medicine into clinical trials FIFA 2026开球时间 as quickly as possible,” said Robert A. Bradway, chairman and chief executive officer at Amgen.

Adaptive will extend its high throughput platform 世界杯直播频道 to rapidly 世界杯直播频道 screen the massive genetic diversity of the B cell receptors from individuals that have recovered from COVID-19. This enables the identification of 世界杯直播频道 tens of thousands of naturally occurring antibodies from FIFA 2026开球时间 survivors of COVID-19 to select those that neutralize SARS-CoV-2. Amgen will then leverage its world-class antibody engineering and drug development FIFA 2026开球时间 capabilities to select, develop and manufacture antibodies designed to bind and neutralize SARS-CoV-2. deCODE Genetics, a subsidiary of Amgen located in Iceland, FIFA 2026开球时间 will provide genetic insights from patients 2026世界杯直播赛程 FIFA 2026开球时间 FIFA 2026开球时间 世界杯直播频道 世界杯直播频道 who were previously infected with COVID-19.

“We are extremely motivated to join forces with 2026世界杯直播赛程 our trusted partner, Amgen, to tackle this global health crisis,” said Chad Robins, chief executive officer and co-founder of Adaptive Biotechnologies. “This partnership 世界杯直播频道 世界杯直播频道 世界杯直播频道 expands our 世界杯直播频道 drug discovery capabilities, demonstrating the power and versatility of our immune medicine platform.”

The two companies have signed a Memorandum of Understanding to enable the parties to start FIFA 2026开球时间 work immediately and are planning to execute a Collaboration and License Agreement. Terms of the agreement 2026世界杯直播赛程 are 世界杯直播频道 not being 世界杯直播频道 世界杯直播频道 FIFA 2026开球时间 disclosed. Both companies aim to FIFA 2026开球时间 accelerate the development of a potential antibody against COVID-19 as fast as possible for patients in need.

About Amgen

Amgen is committed to unlocking the potential of 世界杯直播频道 biology for patients suffering from serious illnesses by discovering, developing, manufacturing and delivering innovative human therapeutics. This FIFA 2026开球时间 approach begins 2026世界杯直播赛程 by using tools like advanced human genetics to unravel 2026世界杯直播赛程 the complexities of disease and understand the fundamentals of human biology.

Amgen focuses on areas of high unmet medical need and leverages its biologics manufacturing expertise to strive 2026世界杯直播赛程 for solutions that improve health outcomes and dramatically improve people’s lives. A biotechnology 世界杯直播频道 pioneer since 1980, Amgen has grown to be the world’s largest independent biotechnology company, 世界杯直播频道 has reached millions of patients around the world FIFA 2026开球时间 and is developing a pipeline of medicines with breakaway 世界杯直播频道 世界杯直播频道 世界杯直播频道 世界杯直播频道 2026世界杯直播赛程 2026世界杯直播赛程 FIFA 2026开球时间 potential. 世界杯直播频道

For more information, visit www.amgen.com and follow us on www.twitter.com/amgen.

About Adaptive Biotechnologies

Adaptive Biotechnologies is a commercial-stage biotechnology company focused on harnessing the inherent biology of the adaptive immune system to transform the diagnosis and treatment of disease. We believe the 2026世界杯直播赛程 adaptive immune system is nature’s most finely tuned diagnostic and therapeutic for most diseases, but the inability to decode it has prevented the medical community from fully leveraging its capabilities. 2026世界杯直播赛程 Our proprietary immune medicine platform reveals and 2026世界杯直播赛程 translates the massive genetics of the adaptive immune system with scale, FIFA 2026开球时间 precision and speed to develop products in life sciences research, clinical FIFA 2026开球时间 世界杯直播频道 FIFA 2026开球时间 2026世界杯直播赛程 2026世界杯直播赛程 FIFA 2026开球时间 世界杯直播频道 世界杯直播频道 diagnostics, and drug discovery. We have two commercial products, and a robust clinical pipeline FIFA 2026开球时间 to diagnose, monitor and enable the treatment of diseases such as cancer, autoimmune conditions and infectious diseases. Our goal is to develop and commercialize immune-driven clinical products tailored to each individual patient. For more information, please visit FIFA 2026开球时间 世界杯直播频道 2026世界杯直播赛程 adaptivebiotech.com and follow us on www.twitter.com/adaptivebiotech.

Amgen Forward-Looking Statements

This communication contains forward-looking statements that are based on the current expectations and beliefs of Amgen. All statements, other than statements of historical fact, are statements that could be FIFA 2026开球时间 FIFA 2026开球时间 世界杯直播频道 FIFA 2026开球时间 deemed forward-looking statements, including any statements on the outcome, benefits and synergies of collaborations, or potential collaborations,  with FIFA 2026开球时间 any other company, FIFA 2026开球时间 including Adaptive Biotechnologies 2026世界杯直播赛程 (including 世界杯直播频道 statements regarding such collaboration’s ability to discover and develop fully-human neutralizing 世界杯直播频道 antibodies targeting SARS-CoV-2 to potentially prevent or treat COVID-19), BeiGene, Ltd., or 世界杯直播频道 2026世界杯直播赛程 the Otezla® (apremilast) acquisition, including anticipated Otezla sales growth and the timing of non-GAAP EPS accretion, as well as estimates of 世界杯直播频道 revenues, operating margins, capital expenditures, cash, 世界杯直播频道 2026世界杯直播赛程 other financial metrics, FIFA 2026开球时间 expected legal, arbitration, political, regulatory or clinical results or practices, customer and prescriber patterns or practices, reimbursement activities and outcomes, effects FIFA 2026开球时间 of pandemics or other widespread health problems such as the ongoing COVID-19 pandemic on our business, and other such estimates and results. Forward-looking statements involve significant risks and uncertainties, FIFA 2026开球时间 including those discussed below and more fully described in the Securities and Exchange Commission reports filed by Amgen, including our most recent annual report on Form 10-K and any subsequent periodic reports 2026世界杯直播赛程 on Form 10-Q and current reports on FIFA 2026开球时间 Form 8-K. Unless otherwise noted, Amgen is providing this information as of the date FIFA 2026开球时间 of this news release and does not undertake any obligation to update any forward-looking 世界杯直播频道 statements FIFA 2026开球时间 contained 世界杯直播频道 in this document as a result of new information, future events or otherwise.

No forward-looking FIFA 2026开球时间 statement can be guaranteed and actual results may differ materially from those we project. Our results may be affected by our ability to successfully market both new and existing products 世界杯直播频道 FIFA 2026开球时间 FIFA 2026开球时间 2026世界杯直播赛程 FIFA 2026开球时间 domestically and internationally, clinical and regulatory developments involving current and future products, sales growth of recently launched products, 世界杯直播频道 competition from other products including biosimilars, FIFA 2026开球时间 difficulties or 世界杯直播频道 delays in manufacturing our products and global economic conditions. In addition, sales of our 世界杯直播频道 products are FIFA 2026开球时间 affected by pricing pressure, political and public scrutiny and reimbursement policies FIFA 2026开球时间 FIFA 2026开球时间 世界杯直播频道 FIFA 2026开球时间 imposed by third-party payers, including governments, private insurance plans and managed care providers and may be affected by regulatory, clinical and guideline developments and domestic and international 世界杯直播频道 世界杯直播频道 trends toward managed care and healthcare cost containment. Furthermore, our research, testing, pricing, marketing and other operations are subject to extensive regulation by domestic and foreign 世界杯直播频道 government FIFA 2026开球时间 世界杯直播频道 FIFA 2026开球时间 regulatory authorities. We or others could identify safety, side effects or manufacturing problems with our products, including our devices, after they are on the market. Our business may be impacted by FIFA 2026开球时间 世界杯直播频道 FIFA 2026开球时间 government investigations, litigation and product FIFA 2026开球时间 liability claims. In addition, our 世界杯直播频道 business may be impacted 2026世界杯直播赛程 by the adoption of new 世界杯直播频道 tax legislation or exposure to additional tax liabilities. FIFA 2026开球时间 If we fail to meet the compliance obligations in the corporate integrity agreement between us and the U.S. government, we could become subject to significant sanctions. Further, while we routinely obtain patents for 2026世界杯直播赛程 FIFA 2026开球时间 our products and technology, the protection offered by our patents and patent applications FIFA 2026开球时间 世界杯直播频道 may be challenged, invalidated or circumvented by our competitors, or we may fail to prevail in present and future 世界杯直播频道 2026世界杯直播赛程 intellectual property litigation. We perform a substantial amount of our commercial manufacturing activities at a few key facilities, including in Puerto Rico, and also depend on third parties for a portion 世界杯直播频道 2026世界杯直播赛程 世界杯直播频道 世界杯直播频道 of our manufacturing activities, and limits on supply may constrain sales of certain of our current products and product candidate development. An outbreak of disease or similar public health threat, such as COVID-19, and the public and governmental 世界杯直播频道 effort to mitigate against the 世界杯直播频道 spread of such disease, could have a significant adverse effect on the supply of materials for our manufacturing activities, the 世界杯直播频道 FIFA 2026开球时间 distribution of our products, the commercialization of our product candidates, and our clinical trial operations, and any such events may have a material adverse effect on our product sales, business and 世界杯直播频道 FIFA 2026开球时间 results of operations. We FIFA 2026开球时间 rely on collaborations with third parties for the development of 2026世界杯直播赛程 some of our product candidates and for the commercialization and sales of some of our commercial products. In addition, 世界杯直播频道 FIFA 2026开球时间 we compete with other companies with respect to many of our marketed products as well as for the discovery and development of new FIFA 2026开球时间 products. Discovery or identification of new product candidates or development FIFA 2026开球时间 of new 2026世界杯直播赛程 indications for existing products cannot be guaranteed and movement from concept to product is uncertain; consequently, there can be no guarantee that any particular FIFA 2026开球时间 product candidate or development 世界杯直播频道 世界杯直播频道 of a new indication for an existing product will be successful and become a commercial product. Further, some raw materials, medical devices and component parts for our products are supplied by sole third-party 2026世界杯直播赛程 2026世界杯直播赛程 世界杯直播频道 suppliers. Certain of our distributors, customers and payers have substantial purchasing leverage in their dealings with 世界杯直播频道 us. The discovery of significant problems with a product similar to one of our products FIFA 2026开球时间 that implicate an entire class of products could have a material adverse effect on sales of the affected products and on our business and 2026世界杯直播赛程 results of operations. Our efforts to collaborate with or acquire 世界杯直播频道 other companies, FIFA 2026开球时间 products or technology, and to integrate the operations of companies or to support the products or technology 世界杯直播频道 we have acquired, may not be successful. A breakdown, cyberattack or information 2026世界杯直播赛程 security breach could 世界杯直播频道 compromise the confidentiality, integrity and availability of our systems and our data. Our stock price is volatile and may be affected by a number of events. Our business performance FIFA 2026开球时间 2026世界杯直播赛程 could affect or limit the ability of our Board of Directors to declare a dividend or our ability to pay a 2026世界杯直播赛程 dividend or repurchase our common stock. We may not be able to access the capital and credit markets FIFA 2026开球时间 FIFA 2026开球时间 on terms that are favorable to us, or 世界杯直播频道 at 世界杯直播频道 all.

Adaptive Forward-Looking Statements

This press release contains forward-looking statements that are based on management’s beliefs and assumptions and on information currently available to management. All statements contained in this release other FIFA 2026开球时间 than statements of historical fact are forward-looking statements, 2026世界杯直播赛程 including statements regarding the ability to extend our platform to identify and select antibodies or other adaptive immune responses to COVID-19 from samples, the ability to leverage our intended collaboration with 世界杯直播频道 Amgen and FIFA 2026开球时间 any findings arise therefrom to advance solutions to diagnose, treat and 世界杯直播频道 prevent COVID-19, enter into a definitive FIFA 2026开球时间 FIFA 2026开球时间 collaboration FIFA 2026开球时间 and FIFA 2026开球时间 licensing agreement with Amgen and fulfill our obligations thereunder, as well as statements regarding our ability to develop, commercialize and achieve market acceptance of our current 2026世界杯直播赛程 FIFA 2026开球时间 and planned products and services, our research and development efforts, and other matters 世界杯直播频道 regarding our business strategies, use of capital, results of operations and financial position, and plans and objectives FIFA 2026开球时间 2026世界杯直播赛程 FIFA 2026开球时间 FIFA 2026开球时间 for future operations.

In FIFA 2026开球时间 some cases, you 世界杯直播频道 can identify forward-looking statements by the words “may,” “will,” “could,” “would,” “should,” “expect,” “intend,” “plan,” “anticipate,” 世界杯直播频道 “believe,” “estimate,” “predict,” “project,” “potential,” 2026世界杯直播赛程 FIFA 2026开球时间 “continue,” “ongoing” or the 世界杯直播频道 negative of these 世界杯直播频道 terms or other comparable terminology, although not all forward-looking statements contain these words. These statements involve risks, uncertainties and other 世界杯直播频道 FIFA 2026开球时间 factors that may cause actual results, levels of activity, performance or achievements to be materially different from the information expressed or implied by these forward-looking statements. These risks, FIFA 2026开球时间 世界杯直播频道 2026世界杯直播赛程 uncertainties and other factors 2026世界杯直播赛程 are described under "Risk Factors," "Management's Discussion and Analysis of Financial Condition and Results of Operations" and elsewhere in the documents we file with the 世界杯直播频道 世界杯直播频道 Securities and Exchange Commission from time to time. We caution you that forward-looking statements are based on a combination of facts and factors currently known by us and our projections FIFA 2026开球时间 of the future, FIFA 2026开球时间 FIFA 2026开球时间 about which we cannot be certain. As a result, the 世界杯直播频道 forward-looking statements may not prove to be accurate. The forward-looking statements in this press release represent our views as of the date hereof. FIFA 2026开球时间 We undertake no obligation to update any forward-looking statements for any reason, except as required by law.