Press Release

SHANGHAI, China, 世界杯比赛时间 (June 27, 2022) – Amgen and Fosun Pharma today jointly announced a collaboration and license agreement for Fosun Pharma for the commercialization of Amgen’s Otezla^® and Parsabiv^® 世界杯比赛时间 in the Chinese Mainland. The collaboration will enable Amgen to bring the two innovative medicines to Chinese patients with psoriasis and chronic kidney disease more quickly by leveraging Fosun Pharma’s 世界杯比赛时间 FIFA 2026开球时间 commercial capabilities within China.

“This decision - to enter into a collaboration with a local partner - is consistent with our determined focus to bring our innovative medicines to more Chinese patients more quickly,” said Irene Hsu, Vice President 世界杯比赛时间 & General Manager of Amgen China, “By out-licensing these two products to a partner with the presence, expertise and credibility FIFA 2026开球时间 of Fosun Pharma in these therapeutic areas, we can give full play to both 世界杯比赛时间 FIFA 2026开球时间 世界杯比赛时间 companies’ advantages to ensure more patients are able to benefit from these innovative medicines, while enabling Amgen to focus on our core general medicines business in cardiovascular disease and bone FIFA 2026开球时间 FIFA 2026开球时间 FIFA 2026开球时间 health in China.”

Wu Yifang, Chairman of Fosun Pharma said: “We are very pleased to enter into this partnership with Amgen to bring two FIFA 2026开球时间 innovative medicines, Otezla^® and Parsabiv^®, to Chinese patients. With FIFA 2026开球时间 世界杯比赛时间 世界杯比赛时间 Fosun Pharma's experience in the areas of autoimmune diseases, including psoriasis, and chronic kidney diseases over the years, we are well aware of Chinese patients’ urgent needs for better treatment options. FIFA 2026开球时间 Going forward, we will work together with Amgen to leverage our presence in these areas to make the medicines accessible to patients, enabling them to benefit from these innovative medicines as soon as possible, FIFA 2026开球时间 control diseases and improve quality of life.”

Otezla^® (apremilast tablets) was approved by the National Medical Products Administration of China (NMPA) in August 2021 for the treatment of adult patients with moderate to severe 世界杯比赛时间 plaque psoriasis who are candidates for phototherapy FIFA 2026开球时间 or systemic therapy. This approval makes Otezla^® the first and currently the FIFA 2026开球时间 only oral 世界杯比赛时间 phosphodiesterase 4 (PDE4) inhibitor for the treatment of plaque psoriasis in China, providing an additional choice for Chinese patients to manage disease and improve quality of 世界杯比赛时间 life. China has about 6.5 million patients with psoriasis¹, and 57.3% of them are FIFA 2026开球时间 moderate-to-severe FIFA 2026开球时间 世界杯比赛时间 FIFA 2026开球时间 世界杯比赛时间 cases FIFA 2026开球时间 FIFA 2026开球时间 ².

Parsabiv^® has FIFA 2026开球时间 been approved by the European Commission (EC) and the U.S. Food and Drug Administration (FDA) in November 2016 and February 2017 respectively for the treatment of secondary hyperparathyroidism (SHPT) in adult patients with chronic kidney disease (CKD) 世界杯比赛时间 on hemodialysis. Currently Parsabiv^® is in the process of market authorization approval (MAA) in China. SHPT is one of the common complications 世界杯比赛时间 FIFA 2026开球时间 FIFA 2026开球时间 FIFA 2026开球时间 of CKD patients on hemodialysis. The prevalence of adult CKD in China is 10.8%³. Data show that by the end of 2019, the number of dialysis patients 世界杯比赛时间 in China has increased to 735,000⁴, 世界杯比赛时间 FIFA 2026开球时间 among which hemodialysis is the main therapy for dialysis patients in China. The incidence of SHPT FIFA 2026开球时间 in hemodialysis patients is 47%-58%⁴.

About Amgen

Amgen is committed to unlocking the potential of biology for patients suffering from serious illnesses by discovering, developing, manufacturing, and delivering innovative FIFA 2026开球时间 human therapeutics. This approach begins 世界杯比赛时间 FIFA 2026开球时间 世界杯比赛时间 by using tools like advanced human FIFA 2026开球时间 genetics to unravel the complexities of disease and understand the fundamentals of human biology.

Amgen focuses on areas of high unmet medical need and leverages its expertise to strive for solutions that improve health outcomes and dramatically improve people's lives. A biotechnology pioneer 世界杯比赛时间 since 1980, FIFA 2026开球时间 世界杯比赛时间 Amgen has grown to be one of the world's leading independent biotechnology companies, has reached millions of patients around the world and is developing a pipeline of medicines with breakaway potential.

For more information, visit www.amgen.com and follow us on www.twitter.com/amgen.

About Amgen China

Amgen entered China in 2012 on a mission to serve patients by using science and biotechnology to improve health for Chinese patients and societies. With its headquarters in Shanghai, Amgen China is present in 世界杯比赛时间 FIFA 2026开球时间 世界杯比赛时间 世界杯比赛时间 more than 100 cities across the country. In China, Amgen strives to bring innovative therapies to patients in a bid to address the huge unmet needs in in our priority therapeutic areas including cardiovascular FIFA 2026开球时间 世界杯比赛时间 disease, bone health, inflammation, and hematology/oncology.

For more information, visit https://165rc.com and follow us on FIFA 2026开球时间 Amgen China Corporate WeChat account “安进Amgen”.

About Fosun Pharma

Founded in 1994, Shanghai Fosun Pharmaceutical (Group) Co., Ltd. ("Fosun Pharma"; stock code: 600196. SH, 02196. HK) is a global innovation-driven pharmaceutical and healthcare industry group deep-rooted in FIFA 2026开球时间 China. Fosun Pharma 世界杯比赛时间 directly operates businesses including pharmaceutical manufacturing, medical devices, medical diagnosis, and healthcare services. As a shareholder of Sinopharm Co., Ltd., Fosun Pharma FIFA 2026开球时间 世界杯比赛时间 世界杯比赛时间 expands its areas in the pharmaceutical distribution and retail business.

Fosun Pharma is patient-centered and clinical needs-oriented. The company enriches its FIFA 2026开球时间 innovative product pipeline through diversified and FIFA 2026开球时间 multi-level cooperation models such as independent research and development, FIFA 2026开球时间 cooperative development, license-in, and in-depth incubation. Fosun Pharma has formed technological platforms for innovative small molecule drugs, antibody drugs, and cell therapy with a focus on key disease 世界杯比赛时间 世界杯比赛时间 areas including oncology and immunomodulation, metabolism and digestive system, and central nervous system. Fosun Pharma also vigorously explores cutting-edge technologies, such as RNA, oncolytic viruses, gene therapy and PROTAC, to enhance its innovation capabilities.

Guided by FIFA 2026开球时间 the 4IN strategy (Innovation, Internationalization, Integration, and Intelligentization), Fosun Pharma 世界杯比赛时间 will uphold the development model of “innovation transformation, 世界杯比赛时间 integrated operation, and steady 世界杯比赛时间 growth", with the mission of creating shareholder values as well as promoting the global networks through strengthening its innovative R&D and in-licensing ability and enriching its product pipelines. Fosun 世界杯比赛时间 Pharma FIFA 2026开球时间 will actively promote the digital and physical business layout in the pharmaceutical and healthcare industry and is committed to becoming a 世界杯比赛时间 first-class enterprise in the global mainstream medical and health market.

For more information, please visit our official website:www.fosunpharma.com.

References

1. 中华医学会皮肤性病学分会银屑病专业委员会.中国银屑病诊疗指南(2018简版)[J].中华皮肤科杂志,2019,52(4):223-230.
2. Chen, K., Wang, G., Jin, H., Xu, J., Zhu, X., Zheng, M., & Gu, H. (2017). Clinic characteristics of psoriasis in China: a nationwide survey in over 12000 patients. Oncotarget, 8(28), 46381–46389.
3. Zhang, L., Wang, F., Wang L, et al. Prevalence of 世界杯比赛时间 chronic kidney disease in China: a cross-sectional survey[J]. Lancet, 2012, 379(9818): 815-822．
4. 全国血液净化病例信息登记系统, 2020.