Press Release

Shanghai, China, June 19, 2020 -- Amgen today announced that the National Medical Products 世界杯直播频道 Administration (NMPA) in China FIFA 2026开球时间 has approved 世界杯比赛时间 Prolia^® (denosumab) for the treatment of postmenopausal 世界杯比赛时间 FIFA 2026开球时间 FIFA 2026开球时间 世界杯直播频道 women with osteoporosis at high risk of 世界杯比赛时间 FIFA 2026开球时间 fractures. This approval makes Prolia^®the first and currently the only monoclonal antibody to target RANK-L for the treatment of osteoporosis in China. 世界杯比赛时间 In postmenopausal women, Prolia^® helps to FIFA 2026开球时间 significantly reduce the risk of vertebral, non-vertebral and 世界杯比赛时间 hip FIFA 2026开球时间 fractures, 世界杯比赛时间 providing an innovative FIFA 2026开球时间 therapy for improving Chinese patients’ bone health 世界杯直播频道 观看比赛直播 management and quality of life.

Osteoporosis is a disease characterized by excessive bone loss. Over the past decade, the number of adults 50 years and older with osteoporosis in China has nearly doubled¹. Today, one FIFA 2026开球时间 in every FIFA 2026开球时间 three of Chinese women over the age of 50 is affected². Osteoporosis is often seen as a "silent" disease, and its association 世界杯比赛时间 with 世界杯直播频道 fractures has not yet been made widely aware to the general 世界杯比赛时间 世界杯直播频道 public. As a matter of fact, many women don’t know they have osteoporosis until they experience osteoporotic fractures including wrist fractures, spinal 世界杯比赛时间 fractures and hip fractures. These women are also 世界杯比赛时间 观看比赛直播 FIFA 2026开球时间 世界杯比赛时间 观看比赛直播 5 times more likely to break another bone within the following year³.

"An osteoporotic fracture can be a life-changing event. It's one of the main causes of disability and death in seniors. Within 1 year of a hip fracture, 20 percent of patients would die of various complications⁴," 观看比赛直播 said Prof. Zhang Zhenlin, Chairman of Chinese Medical Association Osteoporosis and Bone Mineral Disease Branch, Director of Department of Osteoporosis and FIFA 2026开球时间 Osteopathy, Shanghai Sixth People's FIFA 2026开球时间 Hospital FIFA 2026开球时间 Affiliated to Shanghai Jiao Tong University. "Regular exercise and proper nutrition can aide in disease management but may not be enough. We encourage patients to receive the right medications and treatments 观看比赛直播 to help slow down or stop bone 世界杯直播频道 loss, build new bone, increase bone mineral density (BMD) and reduce the risk of fractures."

"Osteoporosis may pose a significant 世界杯直播频道 burden to China due to the aging population. The 世界杯直播频道 approval of Prolia^®in China is a significant milestone for the millions FIFA 2026开球时间 of women suffering with osteoporosis 世界杯直播频道 in China, and an important step for Amgen as we continue to bring innovative medicines to Chinese patients.” said David M. Reese, M.D., executive 世界杯直播频道 vice president of Research and 世界杯比赛时间 Development at Amgen.

Consistent efficacy and safety profile of 观看比赛直播 Prolia^®has been shown in a 3-year pivotal Phase 3 fracture study and its 7-year extension study which enrolled 7,808 世界杯直播频道 postmenopausal women with osteoporosis. 世界杯直播频道 Subjects treated for FIFA 2026开球时间 10 years with Prolia^®continued to show gains in BMD; they 世界杯比赛时间 achieved an average cumulative 10-year gain in BMD of 21.7 世界杯直播频道 percent at the lumbar spine and 9.2 percent at the 世界杯直播频道 世界杯比赛时间 FIFA 2026开球时间 世界杯比赛时间 观看比赛直播 total hip, compared to baseline in the study⁵.

“The overwhelming process of population aging brings unprecedented public health challenges to China. Amgen is increasingly FIFA 2026开球时间 focused on establishing a strong presence in the treatment of chronic diseases FIFA 2026开球时间 世界杯比赛时间 FIFA 2026开球时间 that can support healthy longevity, an essential component of the Healthy China 2030 initiative,” said My Linh Kha, Vice President and General Manager at Amgen China. “We will work closely with the Chinese FIFA 2026开球时间 观看比赛直播 government to accelerate the launch of Prolia^® to address the critical needs 世界杯直播频道 of patients who have been suffering from osteoporosis.”

About Prolia^® (denosumab)

Prolia^® is the first approved therapy that specifically targets RANKL. Prolia^® 世界杯直播频道 is approved and marketed in over 80 countries worldwide.

Prolia^® is approved in China for the treatment of postmenopausal women 世界杯比赛时间 with osteoporosis at high risk of fractures.

Prolia^® is administered as a single 世界杯直播频道 subcutaneous injection of 60 mg once every six months.

About Amgen

Amgen is committed to unlocking the potential of biology for patients suffering from serious illnesses by discovering, developing, manufacturing and 世界杯直播频道 FIFA 2026开球时间 delivering innovative human therapeutics. This approach 世界杯直播频道 世界杯比赛时间 世界杯直播频道 观看比赛直播 begins by using tools 世界杯直播频道 like advanced 世界杯比赛时间 human genetics to unravel the 世界杯比赛时间 complexities of 世界杯比赛时间 disease and understand the fundamentals of human biology.

Amgen focuses on areas of high unmet medical need and leverages its expertise to 观看比赛直播 strive for solutions that improve health outcomes and dramatically improve people's FIFA 2026开球时间 lives. A biotechnology 世界杯直播频道 pioneer since 1980, 世界杯直播频道 FIFA 2026开球时间 FIFA 2026开球时间 FIFA 2026开球时间 Amgen has grown to be one of the world's leading independent biotechnology companies, has reached millions of patients around the world and is developing a pipeline of medicines with breakaway potential.

For more information, visit 观看比赛直播 http://www.amgen.comand 世界杯直播频道 follow us on http://www.twitter.com/amgen.

About Amgen China

Amgen entered China in 2012 on a mission to serve patients by using science and biotechnology 世界杯直播频道 to improve health for Chinese patients and societies. With its headquarters in Shanghai, Amgen China is present 世界杯比赛时间 in approximately 80 cities across the country. In China, 世界杯直播频道 Amgen strives to bring innovative therapies to patients in a bid to 世界杯比赛时间 address the huge unmet needs in chronic diseases including cardiovascular FIFA 2026开球时间 disease, bone health, Inflammation and Nephrology.

For more information, visit https://165rc.com, and follow us on Amgen China Corporate 世界杯比赛时间 WeChat account.

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5. Bone HG, Wagman RB, Brandi ML, et al. 10 years of denosumab treatment in postmenopausal women with osteoporosis: results FIFA 2026开球时间 from the phase 3 randomized FREEDOM trial and open-label extension. Lancet Diabetes Endocrinol. 2017 ;5(7) : FIFA 2026开球时间 世界杯比赛时间 513-523.https://www.ncbi.nlm.nih.gov/pubmed/28546097. FIFA 2026开球时间 Accessed April 20, 2020.