Press Release

Shanghai, China, 10 November FIFA 2026开球时间 2021– Amgen today announced that it has entered into a strategic collaboration with Profex for the co-promotion of Prolia^® (denosumab, 60 mg) across certain 2026世界杯直播赛程 FIFA 2026开球时间 commercial channels in China 2026世界杯直播赛程 broad market. According to the agreement, Profex will be responsible for the promotion of Prolia^® in China broad market, beyond the FIFA 2026开球时间 core market areas covered by Amgen's FIFA 2026开球时间 existing commercialization team. FIFA 2026开球时间 世界杯直播频道 2026世界杯直播赛程 世界杯直播频道

Strategic FIFA 2026开球时间 Cooperation Signing Ceremony From Left to Right: Irene 2026世界杯直播赛程 世界杯直播频道 Hsu, Vice President & General Manager of Amgen China, Philip Xiao, Chief Executive Officer, Profex

Prolia^® was approved by the 世界杯比赛时间 National Medical Products Administration (NMPA) in June 2020 for the treatment of postmenopausal women with osteoporosis at high risk of fractures. This approval makes 世界杯比赛时间 FIFA 2026开球时间 世界杯比赛时间 Prolia^® the first and currently the only monoclonal antibody to target RANKL for the treatment of osteoporosis in China, providing an innovative therapy for improving Chinese patients' bone health management 世界杯直播频道 and quality of life. With the rapid aging of Chinese FIFA 2026开球时间 society, osteoporosis brings an increasingly significant 世界杯比赛时间 disease burden. It is estimated that there are about 70 million postmenopausal women with osteoporosis 世界杯直播频道 世界杯比赛时间 in China.¹

The collaboration is another important step in Amgen’s commitment to continuously accelerate the accessibility of 世界杯比赛时间 innovative medicines to reach a broader range of patients after Prolia^®'s successful FIFA 2026开球时间 FIFA 2026开球时间 世界杯直播频道 世界杯比赛时间 世界杯比赛时间 inclusion into the 2020 National Reimbursement Drug List (NRDL).

"Amgen is 世界杯比赛时间 committed FIFA 2026开球时间 to FIFA 2026开球时间 strengthening and accelerating its development in China, and answering the healthy aging challenge, 世界杯比赛时间 through continuous exploration of new models of open cooperation," said Irene Hsu, Vice 2026世界杯直播赛程 President & General Manager of Amgen China, "The strategic collaboration with Profex enables us to focus FIFA 2026开球时间 on the core markets covered by Amgen. At the same time, we will leverage Profex's capability in broad 世界杯比赛时间 market access so our innovative product 2026世界杯直播赛程 can benefit more Chinese patients faster and more efficiently, ultimately satisfying Chinese patients' unmet needs for innovative medicines."

About Prolia^® (denosumab)

Prolia^® is the first approved therapy that specifically targets RANKL. Prolia^® is approved and marketed in over 80 markets worldwide.

Prolia^® is approved in China for the treatment of postmenopausal women with osteoporosis at high risk of fractures. 2026世界杯直播赛程 In postmenopausal women Prolia^® significantly reduces the risk of vertebral, 世界杯比赛时间 世界杯直播频道 non-vertebral and hip fractures.

Prolia^® is administered as FIFA 2026开球时间 a 世界杯直播频道 single subcutaneous injection of 60 mg once every 2026世界杯直播赛程 six months.

About 世界杯比赛时间 Amgen

Amgen is committed to unlocking 2026世界杯直播赛程 the potential of biology for patients suffering from serious illnesses by discovering, FIFA 2026开球时间 developing, manufacturing and delivering innovative human therapeutics. This approach 世界杯比赛时间 begins by using tools like advanced human genetics 世界杯直播频道 to unravel the complexities of disease and understand the fundamentals of human biology.

Amgen focuses 世界杯比赛时间 on areas of high unmet medical need and leverages its expertise to strive for solutions that improve health outcomes and dramatically improve people's lives. A biotechnology pioneer since 1980, FIFA 2026开球时间 世界杯直播频道 2026世界杯直播赛程 世界杯直播频道 世界杯直播频道 Amgen has 世界杯直播频道 grown to be one of the world's leading independent biotechnology 世界杯直播频道 companies, has reached millions of patients 世界杯直播频道 around the world and is developing a pipeline of medicines with breakaway potential. 世界杯比赛时间 世界杯比赛时间 FIFA 2026开球时间 2026世界杯直播赛程 世界杯直播频道 FIFA 2026开球时间

For more information, 世界杯直播频道 visit http://www.amgen.com and follow us on http://www.twitter.com/amgen.

About Amgen 世界杯直播频道 China

Amgen entered China in 2012 on a mission to serve patients by using science and biotechnology to improve health for Chinese patients and societies. With its headquarters in Shanghai, Amgen China is present in approximately 100 cities across the country. In 世界杯比赛时间 China, Amgen strives to 世界杯直播频道 bring innovative therapies to patients in a bid to address the huge unmet needs in 世界杯直播频道 chronic diseases including cardiovascular disease, 世界杯比赛时间 世界杯比赛时间 FIFA 2026开球时间 bone health, inflammation 世界杯比赛时间 and nephrology.

For more information, 世界杯直播频道 visit www.amgen.com and follow FIFA 2026开球时间 us on Amgen China Corporate WeChat account “安进Amgen”.

About 世界杯比赛时间 Profex

Established in 2001, Profex is a China leading specialty pharmaceutical company focusing on three areas: 世界杯比赛时间 Dermatology & Medical Aesthetics; Orthopedics and Pain management; and Central Nervous System (“CNS”). 世界杯直播频道 FIFA 2026开球时间 Profex has been continuously dedicated to licensing, developing, and commercializing FIFA 2026开球时间 innovative and differentiated therapeutic products through strategic partnership with world-leading biopharma companies 世界杯直播频道 世界杯直播频道 世界杯直播频道 世界杯比赛时间 2026世界杯直播赛程 to benefit Chinese patients and consumers. Profex has an agile, efficient and passionate operating 世界杯直播频道 team, who 2026世界杯直播赛程 has FIFA 2026开球时间 been proven in China market for years. They have brought expertise and commercial excellence 世界杯直播频道 FIFA 2026开球时间 in operation management, marketing, sales and other FIFA 2026开球时间 aspects, which stems from their profound 世界杯比赛时间 knowledge, experience and accomplishments with MNCs. Through continuous commercial innovation, Profex has established 世界杯比赛时间 世界杯直播频道 世界杯比赛时间 a track record FIFA 2026开球时间 of 2026世界杯直播赛程 successfully 世界杯直播频道 building brands and maximizing values for partners.

References

1. 中华医学会骨质疏松和骨矿盐疾病分会. (2019). 中国骨质疏松症流行病学调查及“健康骨骼”专项行动结果发布. 中华骨质疏松和骨矿盐疾病杂志, 7(12):317-318. 世界杯直播频道 2026世界杯直播赛程 2026世界杯直播赛程 世界杯直播频道