Press Release

THOUSAND OAKS, Calif., 2026世界杯直播赛程 FIFA 2026开球时间 July 21, 2015  -- 观看比赛直播 世界杯直播频道 世界杯直播频道 Amgen (NASDAQ:AMGN) today announced that the 2026世界杯直播赛程 European Commission (EC) has granted marketing authorization for Repatha^™ (evolocumab), the first proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor to be approved 2026世界杯直播赛程 FIFA 2026开球时间 观看比赛直播 观看比赛直播 in the world, for the treatment of patients with uncontrolled cholesterol who require additional FIFA 2026开球时间 intensive low-density lipoprotein cholesterol (LDL-C) reduction. Repatha 2026世界杯直播赛程 is FIFA 2026开球时间 a human monoclonal antibody 世界杯直播频道 观看比赛直播 that inhibits PCSK9, a protein that reduces the liver's ability to remove LDL-C, or "bad" cholesterol, from the blood.¹ Elevated LDL-C is an 世界杯直播频道 abnormality of cholesterol and/or fats in the blood,^{2,3 世界杯直播频道} and FIFA 2026开球时间 is recognized as a major risk factor for cardiovascular disease (CVD).^4,5

To view the multimedia assets associated with this press release, please click: 2026世界杯直播赛程 http://www.multivu.com/players/English/7414052-amgen-repatha/.

The EC approved Repatha for:

• 观看比赛直播 FIFA 2026开球时间 FIFA 2026开球时间 2026世界杯直播赛程 FIFA 2026开球时间 观看比赛直播 The treatment of adults with primary hypercholesterolemia (heterozygous familial and non-familial [HeFH]) or mixed dyslipidemia, as an adjunct to diet: FIFA 2026开球时间 2026世界杯直播赛程
  • in combination with a statin or statin with other lipid-lowering therapies in patients unable to reach LDL-C goals with the maximum tolerated dose of a statin, or
  • alone or in combination with other lipid-lowering therapies in patients who are statin-intolerant, or for whom a statin is FIFA 2026开球时间 contraindicated.
• The treatment of adults and adolescents aged 12 years and over with homozygous familial hypercholesterolemia (HoFH) in combination with other lipid-lowering therapies.

The effect of Repatha on cardiovascular morbidity 观看比赛直播 and 世界杯直播频道 mortality has 观看比赛直播 not yet been determined.

More than 60 percent of high-risk patients in 世界杯直播频道 2026世界杯直播赛程 Europe are still unable to adequately lower their LDL-C levels with statins or other FIFA 2026开球时间 currently approved lipid-lowering agents. Among very high-risk patients, the percentage is 观看比赛直播 increased to 2026世界杯直播赛程 more than 80 FIFA 2026开球时间 percent.^{6 观看比赛直播} The FIFA 2026开球时间 health care cost of CVD in the 世界杯直播频道 观看比赛直播 European Union (EU) is approximately €106 billion per year.⁷

"We are proud that 观看比赛直播 our cholesterol-lowering medication, Repatha, is the first PCSK9 inhibitor to be approved by any regulatory agency in the world," said 世界杯直播频道 Sean E. Harper, M.D., executive vice president FIFA 2026开球时间 of Research and FIFA 2026开球时间 Development at 2026世界杯直播赛程 FIFA 2026开球时间 世界杯直播频道 FIFA 2026开球时间 世界杯直播频道 Amgen. "High LDL cholesterol is a major global health burden and many patients are unable to appropriately control their LDL cholesterol with the maximum tolerated dose of a statin, or 世界杯直播频道 are unable 世界杯直播频道 to take 世界杯直播频道 statins due to intolerance or contraindications. We are excited to make this new cholesterol-lowering medication available for patients in Europe."

One high-risk 世界杯直播频道 patient group includes those with familial hypercholesterolemia 观看比赛直播 (FH), an inherited condition caused by genetic mutations 世界杯直播频道 which lead to high levels 世界杯直播频道 of LDL-C at an early age.⁸ It is 世界杯直播频道 FIFA 2026开球时间 观看比赛直播 2026世界杯直播赛程 FIFA 2026开球时间 2026世界杯直播赛程 世界杯直播频道 estimated that less than one percent 世界杯直播频道 of people with FH (heterozygous and homozygous forms) in most countries are diagnosed.⁹

"Many patients who are taking cholesterol-lowering therapies, including those with 2026世界杯直播赛程 familial hypercholesterolemia, still struggle to control their FIFA 2026开球时间 LDL cholesterol levels," said 世界杯直播频道 观看比赛直播 John J.P. Kastelein, professor of medicine and chairman of the 2026世界杯直播赛程 FIFA 2026开球时间 世界杯直播频道 世界杯直播频道 世界杯直播频道 Department of Vascular Medicine FIFA 2026开球时间 at the 2026世界杯直播赛程 Academic Medical Center (AMC) of the FIFA 2026开球时间 2026世界杯直播赛程 世界杯直播频道 世界杯直播频道 University of Amsterdam. "As the first in a new class of drugs in the 世界杯直播频道 世界杯直播频道 2026世界杯直播赛程 观看比赛直播 European Union, evolocumab will offer physicians an important and innovative 世界杯直播频道 treatment option for patients with uncontrolled cholesterol who 观看比赛直播 require additional LDL cholesterol reduction."

Approval from the EC grants a centralized marketing authorization with unified labeling in the 28 countries that FIFA 2026开球时间 are members of the EU. 世界杯直播频道 世界杯直播频道 Norway, 世界杯直播频道 观看比赛直播 世界杯直播频道 Iceland and FIFA 2026开球时间 FIFA 2026开球时间 Liechtenstein, FIFA 2026开球时间 as members of the European Economic Area (EEA), will take corresponding decisions 观看比赛直播 on the basis of the decision of the EC.

Data show Repatha has demonstrated substantial and consistent reductions in LDL-C levels with supporting beneficial changes in other lipid parameters in approximately 6,000 patients with primary hyperlipidemia FIFA 2026开球时间 FIFA 2026开球时间 世界杯直播频道 and mixed dyslipidemia, including more than 4,500 patients with high cholesterol in 10 Phase 3 trials.¹⁰ In these studies, Repatha significantly 世界杯直播频道 reduced LDL-C by approximately 55 percent to FIFA 2026开球时间 FIFA 2026开球时间 世界杯直播频道 75 percent compared with placebo,^11-14 and by approximately 35 percent to 世界杯直播频道 观看比赛直播 45 percent compared 观看比赛直播 with ezetimibe.^11,12,14 In patients FIFA 2026开球时间 with homozygous FH, Repatha significantly reduced LDL-C by approximately 15 percent to 30 percent compared with placebo.¹⁵ Reduction of LDL-C was maintained with long-term treatment.¹⁶

The adverse event profile for Repatha was comparable overall to that 世界杯直播频道 of the control groups.^11-17 The most common adverse 观看比赛直播 reactions that 世界杯直播频道 occurred in greater than or equal 2026世界杯直播赛程 to 2 percent of the Repatha FIFA 2026开球时间 FIFA 2026开球时间 世界杯直播频道 group, and more frequently than in the control group, were nasopharyngitis, upper respiratory tract infection, back pain, arthralgia, influenza and FIFA 2026开球时间 nausea. Please consult the Summary of Product Characteristics FIFA 2026开球时间 2026世界杯直播赛程 FIFA 2026开球时间 ( FIFA 2026开球时间 FIFA 2026开球时间 SmPC) for full safety information.

Repatha is for subcutaneous injection into the abdomen, thigh or upper 世界杯直播频道 arm 观看比赛直播 region. Injection sites should be rotated and injections should not be given into areas where the skin is tender, bruised, red or 世界杯直播频道 hard. Repatha must not be administered intravenously or intramuscularly. Before starting treatment with FIFA 2026开球时间 Repatha, secondary causes (non-genetic) of excess cholesterol 2026世界杯直播赛程 and abnormal fat levels in blood 观看比赛直播 世界杯直播频道 should be excluded. The medicine can only be obtained with a prescription.

The recommended dose for adults FIFA 2026开球时间 with primary disease is either 140 mg every two weeks or 420 mg (the contents of three pre-filled syringes) 世界杯直播频道 once a FIFA 2026开球时间 month; both doses 观看比赛直播 are clinically equivalent. For adults FIFA 2026开球时间 or children older than 12 years with homozygous FH, the initial recommended dose is 世界杯直播频道 420 观看比赛直播 mg once a month. If a response is not achieved after 12 weeks of treatment, the dose can be increased up to 观看比赛直播 420 观看比赛直播 mg every 世界杯直播频道 two weeks. For more information, see the package leaflet.

About Repatha^TM (evolocumab)

Repatha^™ (evolocumab) is a human monoclonal antibody 世界杯直播频道 that inhibits proprotein convertase subtilisin/kexin 世界杯直播频道 type 9 (PCSK9).¹ PCSK9 is a protein that targets LDL receptors 世界杯直播频道 FIFA 2026开球时间 世界杯直播频道 for degradation and thereby reduces the liver's ability to remove LDL-C, or "bad" cholesterol, from the blood.¹⁸ Repatha, developed by 世界杯直播频道 FIFA 2026开球时间 世界杯直播频道 Amgen scientists, is designed to bind to PCSK9 and inhibit PCSK9 from binding to LDL receptors on the liver surface. In the absence of PCSK9, 观看比赛直播 there are more LDL receptors on the surface 世界杯直播频道 of the FIFA 2026开球时间 liver to remove LDL-C FIFA 2026开球时间 from the blood.¹

Important FIFA 2026开球时间 EU Product 世界杯直播频道 Information

Hypercholesterolemia and mixed dyslipidemia

Repatha is indicated in adults with primary hypercholesterolemia (heterozygous familial and non-familial) or mixed dyslipidemia, as an adjunct to diet:

• in combination with a statin or statin with other lipid lowering therapies in patients unable to reach LDL-C goals with the maximum tolerated dose of a 世界杯直播频道 statin or,
• alone or in combination with other lipid-lowering therapies in patients FIFA 2026开球时间 who are statin-intolerant, or for whom a statin is contraindicated.

Homozygous familial hypercholesterolemia

Repatha is indicated in adults and adolescents aged 12 years and over with homozygous familial hypercholesterolemia in combination with 世界杯直播频道 other lipid-lowering therapies.

The effect of Repatha 世界杯直播频道 on cardiovascular morbidity and mortality has not yet been determined.

Important Safety Information

▼ This medicinal product is subject to additional monitoring. This will allow quick identification of new FIFA 2026开球时间 safety information. Healthcare professionals FIFA 2026开球时间 are asked 世界杯直播频道 to report any suspected adverse reactions. FIFA 2026开球时间 FIFA 2026开球时间 世界杯直播频道 世界杯直播频道

Contraindications: Hypersensitivity to 世界杯直播频道 the active substance or to any of the 世界杯直播频道 excipients.

Special Warnings and Precautions: 世界杯直播频道 Renal impairment: Patients with severe 世界杯直播频道 2026世界杯直播赛程 renal impairment (defined as eGFR < 30 mL/min/1.73 m²) have not been studied. Repatha should be used with 世界杯直播频道 观看比赛直播 2026世界杯直播赛程 世界杯直播频道 世界杯直播频道 caution in patients with FIFA 2026开球时间 severe renal impairment. Hepatic impairment: In patients 2026世界杯直播赛程 with moderate hepatic impairment, a reduction in total evolocumab exposure FIFA 2026开球时间 was observed that may lead to a reduced FIFA 2026开球时间 effect on 世界杯直播频道 LDL‑C reduction. Therefore, close monitoring may be warranted FIFA 2026开球时间 in 观看比赛直播 these patients. Patients with severe hepatic impairment (Child-Pugh C) have not been studied. Repatha should be used with caution 2026世界杯直播赛程 FIFA 2026开球时间 观看比赛直播 in patients with severe hepatic impairment. FIFA 2026开球时间 Dry natural rubber: The needle cover of the glass pre-filled syringe and of the pre-filled pen is made from 世界杯直播频道 dry natural rubber (a derivative of latex), 世界杯直播频道 世界杯直播频道 which may cause allergic FIFA 2026开球时间 reactions. Sodium content: Repatha contains less than 1 mmol sodium (23 mg) per dose, i.e. it is essentially 'sodium-free'.

Interactions: No 观看比赛直播 formal drug-drug interaction studies have been conducted for Repatha. No studies on pharmacokinetic and pharmacodynamics interaction between Repatha and lipid-lowering drugs other FIFA 2026开球时间 2026世界杯直播赛程 观看比赛直播 2026世界杯直播赛程 世界杯直播频道 FIFA 2026开球时间 than statins and ezetimibe have been conducted.

Fertility, Pregnancy and Lactation: There FIFA 2026开球时间 are no or limited amount of data from the use of Repatha in pregnant women. Repatha should not be used during pregnancy unless the clinical condition of the 世界杯直播频道 观看比赛直播 FIFA 2026开球时间 世界杯直播频道 woman requires treatment with evolocumab. It is unknown whether evolocumab is excreted in human milk. A risk to breastfed newborns/infants cannot be excluded. No data on the effect of evolocumab on human 世界杯直播频道 fertility are available.

Undesirable Effects: The 2026世界杯直播赛程 following common (> 1/100 to < 1/10) adverse reactions have been reported in pivotal, 观看比赛直播 controlled clinical studies: influenza, nasopharyngitis, upper respiratory 2026世界杯直播赛程 世界杯直播频道 tract infection, rash, FIFA 2026开球时间 世界杯直播频道 nausea, back pain, arthralgia, injection site reactions. Please consult the FIFA 2026开球时间 FIFA 2026开球时间 观看比赛直播 2026世界杯直播赛程 2026世界杯直播赛程 SmPC for a full description 世界杯直播频道 of undesirable effects.

Pharmaceutical 世界杯直播频道 Precautions: Store in a refrigerator (2 degrees C – 8 degrees C). Do not freeze. FIFA 2026开球时间 Keep the pre-filled 观看比赛直播 syringe or the pre-filled pen FIFA 2026开球时间 in the 观看比赛直播 original carton FIFA 2026开球时间 in order 观看比赛直播 to protect from light. FIFA 2026开球时间 观看比赛直播 FIFA 2026开球时间 If removed from the refrigerator, Repatha may be stored at room temperature (up to 25 degrees C) FIFA 2026开球时间 in the 2026世界杯直播赛程 original carton and must be used within 1 week.

About Amgen Cardiovascular

Building on more than three decades of experience in developing biotechnology medicines for patients with serious illnesses, 2026世界杯直播赛程 世界杯直播频道 2026世界杯直播赛程 FIFA 2026开球时间 Amgen is dedicated to addressing 世界杯直播频道 important scientific questions to advance care and improve the lives of patients with 2026世界杯直播赛程 cardiovascular disease, the leading cause of morbidity and mortality worldwide.¹⁹ Amgen's research into cardiovascular disease, and potential treatment options, is part of a growing competency at FIFA 2026开球时间 2026世界杯直播赛程 FIFA 2026开球时间 Amgen that utilizes human genetics to identify and validate certain drug targets. Through its own research and 2026世界杯直播赛程 development 观看比赛直播 efforts, as well as partnerships, 观看比赛直播 FIFA 观看比赛直播 2026开球时间 Amgen is building a cardiovascular portfolio consisting of several approved and investigational molecules in 世界杯直播频道 an effort to address a number of today's important unmet patient needs, such as high FIFA 2026开球时间 2026世界杯直播赛程 2026世界杯直播赛程 世界杯直播频道 cholesterol and heart failure.

About Amgen

Amgen is committed to unlocking the potential of biology for patients suffering from serious illnesses by discovering, developing, manufacturing and delivering 世界杯直播频道 FIFA 2026开球时间 innovative human therapeutics. This FIFA 2026开球时间 世界杯直播频道 观看比赛直播 2026世界杯直播赛程 approach begins by using tools like advanced FIFA 2026开球时间 human genetics to unravel the complexities of disease and understand the fundamentals of human biology.

Amgen focuses on areas of high unmet medical need and leverages its biologics FIFA 2026开球时间 manufacturing expertise to strive for solutions that 2026世界杯直播赛程 improve health outcomes and dramatically improve people's lives. 2026世界杯直播赛程 世界杯直播频道 世界杯直播频道 世界杯直播频道 A biotechnology pioneer since 1980, 观看比赛直播 世界杯直播频道 FIFA 2026开球时间 FIFA 2026开球时间 Amgen has grown to be one of the world's leading independent biotechnology companies, has reached millions of patients around FIFA 2026开球时间 the world and is developing a pipeline of medicines with breakaway FIFA 2026开球时间 FIFA 2026开球时间 世界杯直播频道 potential. 观看比赛直播 观看比赛直播 观看比赛直播 2026世界杯直播赛程 世界杯直播频道 2026世界杯直播赛程

For more information, visit http://www.amgen.com/ and follow us on www.twitter.com/amgen.

Forward-Looking Statements

This news release contains forward-looking statements that are based on management's current FIFA 2026开球时间 观看比赛直播 expectations and beliefs and are subject to a number of risks, uncertainties and assumptions that could cause FIFA 2026开球时间 actual results to differ materially from those described. All statements, other 观看比赛直播 than 世界杯直播频道 statements of historical fact, are statements that could be deemed forward-looking 世界杯直播频道 statements, including FIFA 2026开球时间 estimates of revenues, operating margins, capital expenditures, cash, other 2026世界杯直播赛程 financial metrics, expected legal, arbitration, political, regulatory or clinical results or practices, customer and prescriber patterns 2026世界杯直播赛程 or practices, reimbursement activities and outcomes and other such estimates and results. 观看比赛直播 Forward-looking statements 2026世界杯直播赛程 involve significant risks and uncertainties, including those discussed below and more 观看比赛直播 fully described in the FIFA 2026开球时间 世界杯直播频道 FIFA 2026开球时间 Securities and Exchange Commission ( 2026世界杯直播赛程 FIFA 2026开球时间 SEC) reports filed by FIFA 2026开球时间 世界杯直播频道 世界杯直播频道 FIFA 2026开球时间 Amgen, including FIFA 2026开球时间 Amgen's most recent annual report on Form 10-K and any FIFA 2026开球时间 subsequent periodic reports on Form 10-Q and Form 8-K. Please refer to 观看比赛直播 世界杯直播频道 2026世界杯直播赛程 Amgen's most recent Forms 10-K, 10-Q and 8-K for additional information on the uncertainties and risk factors related to FIFA 2026开球时间 our business. Unless otherwise noted, 观看比赛直播 Amgen is providing this information 2026世界杯直播赛程 as of July 21, 2015, and expressly disclaims any duty to update information contained in this news release.

No forward-looking statement can be guaranteed 世界杯直播频道 and 观看比赛直播 actual results may differ materially from those we project. Discovery or identification of new product candidates or development of new indications for 世界杯直播频道 existing products cannot be guaranteed and movement from concept to product is uncertain; consequently, there can be FIFA 2026开球时间 no 观看比赛直播 guarantee that any particular product candidate or development of a new FIFA 2026开球时间 indication 观看比赛直播 世界杯直播频道 观看比赛直播 FIFA 2026开球时间 for an existing product will be successful and become a commercial product. Further, preclinical results do not guarantee safe and effective FIFA 2026开球时间 performance of product candidates in humans. The complexity 2026世界杯直播赛程 观看比赛直播 of the human body cannot be perfectly, or sometimes, even adequately FIFA 2026开球时间 modeled by computer or cell culture systems or animal models. The length of time that it takes for us to complete clinical trials FIFA 2026开球时间 FIFA 2026开球时间 and obtain regulatory approval for 2026世界杯直播赛程 product marketing has in the past varied and we expect 世界杯直播频道 similar variability in the future. We develop product candidates internally and through licensing collaborations, FIFA 2026开球时间 partnerships FIFA 2026开球时间 and joint ventures. Product candidates that are derived from relationships may be subject to disputes between the parties or may prove to be not as effective or as safe as we may have believed 世界杯直播频道 世界杯直播频道 FIFA 2026开球时间 at the time of entering into such relationship. Also, we or others could identify safety, side effects or manufacturing problems with our products after they are on the market. Our business may be impacted 世界杯直播频道 by government investigations, litigation and products liability claims. We depend on third parties for a significant portion of FIFA 2026开球时间 our manufacturing capacity for the supply 世界杯直播频道 of certain of our current and FIFA 2026开球时间 世界杯直播频道 future products and limits on supply may constrain sales of certain of our current products and product candidate 观看比赛直播 development.

In addition, sales of our products are affected by the reimbursement policies imposed by third-party payors, including governments, private insurance plans and managed care providers and may be affected FIFA 2026开球时间 FIFA 2026开球时间 世界杯直播频道 by regulatory, clinical and guideline 世界杯直播频道 developments and 2026世界杯直播赛程 domestic and international trends toward managed care and healthcare cost containment as well as U.S. legislation affecting pharmaceutical 世界杯直播频道 pricing 世界杯直播频道 FIFA 2026开球时间 and reimbursement. Government and others' regulations and reimbursement policies may affect the development, usage and pricing of our products. In addition, we compete with other companies with respect FIFA 2026开球时间 世界杯直播频道 to some of our marketed products as well as for the discovery and development of new products. We believe that some of our newer products, product candidates or 2026世界杯直播赛程 new indications for existing products, FIFA 2026开球时间 FIFA 2026开球时间 may face competition when and as they are 世界杯直播频道 approved and marketed. Our products may compete against products that have lower prices, established reimbursement, superior performance, are 世界杯直播频道 easier to administer, or that are otherwise competitive with 2026世界杯直播赛程 our products. In addition, while we routinely obtain patents for our products and technology, the protection offered by our patents and patent applications may be challenged, invalidated or circumvented by our competitors and there can be no guarantee of our ability to obtain or maintain patent protection for our products or product candidates. We cannot guarantee 世界杯直播频道 世界杯直播频道 that we will be able to produce commercially successful products or maintain the commercial 观看比赛直播 2026世界杯直播赛程 success of our existing products. Our stock price may be affected by actual or perceived market opportunity, competitive position, and 观看比赛直播 success or failure of our products or product candidates. Further, the discovery of significant problems FIFA 2026开球时间 with 2026世界杯直播赛程 a product similar to one of 观看比赛直播 our products FIFA 2026开球时间 that implicate an entire 观看比赛直播 世界杯直播频道 世界杯直播频道 class of products could have a material adverse effect on sales of the affected products and FIFA 2026开球时间 on our business and results of operations. Our efforts to integrate the operations of companies we have acquired 世界杯直播频道 世界杯直播频道 FIFA 2026开球时间 世界杯直播频道 FIFA 2026开球时间 may not be successful. We may experience difficulties, delays or unexpected costs and not achieve anticipated benefits and savings 世界杯直播频道 from our recently announced restructuring plan. Our business performance 2026世界杯直播赛程 could affect 观看比赛直播 or limit the ability of our Board of Directors to declare a dividend or their ability to pay a dividend or repurchase our common stock.

The scientific information discussed in this news release related to our product candidates is specific to the 世界杯直播频道 2026世界杯直播赛程 FIFA 2026开球时间 European Union. 世界杯直播频道 Such product candidates are not approved by the U.S. Food and Drug Administration ( 世界杯直播频道 FIFA 2026开球时间 FDA), and no conclusions can or should be drawn regarding the safety or effectiveness of the product candidates in the U.S.

CONTACT: FIFA 2026开球时间 观看比赛直播 Amgen, 世界杯直播频道 观看比赛直播 Thousand Oaks
Kristen Davis, 805-447-3008 (media)
Trish Hawkins, 805-447-5631 (media)
Arvind Sood, 805-447-1060 (investors)

Amgen, Europe
Emma Gilbert, +41 41 369 2542
James Read, 观看比赛直播 +44 1223 436474

References

1. Amgen Data on FIFA 2026开球时间 File, Investigator Brochure.

2. 观看比赛直播 FIFA 2026开球时间 2026世界杯直播赛程 世界杯直播频道 FIFA 2026开球时间 世界杯直播频道 FIFA 2026开球时间 FIFA 2026开球时间 World Health Organization. Quantifying Selected Major Risks to Health. 世界杯直播频道 In: The World Health Report 2002 - Reducing FIFA 2026开球时间 Risks, Promoting Healthy Life. 世界杯直播频道 世界杯直播频道 Geneva. FIFA 2026开球时间 2002:49-97.

3. Merck Manuals website. http://www.merckmanuals.com/professional/endocrine_and_metabolic_disorders/lipid_disorders/dyslipidemia.html. FIFA 2026开球时间 Accessed FIFA 2026开球时间 July 2015.

4. 2026世界杯直播赛程 世界杯直播频道 观看比赛直播 FIFA 2026开球时间 American Heart Association (2014). Why Cholesterol Matters. http://www.heart.org/HEARTORG/Conditions/Cholesterol/WhyCholesterolMatters/Why-Cholesterol-Matters_UCM_001212_Article.jsp. Accessed 观看比赛直播 July 2015.

5. 观看比赛直播 World Health Organization. Global 观看比赛直播 Status Report on Noncommunicable Diseases 2014. FIFA 2026开球时间 世界杯直播频道 世界杯直播频道 Geneva, 2014.

6. Halcox JP, et al. Low Rates of Both Lipid-Lowering Therapy Use and Achievement of Low-Density Lipoprotein Cholesterol Targets in Individuals at High-Risk for 2026世界杯直播赛程 Cardiovascular Disease across FIFA 2026开球时间 2026世界杯直播赛程 Europe. PLoS One. 2015;10(2).

7. Leal J, et al. Economic Costs. In: Nichols M, et al. European Cardiovascular Disease Statistics 2012.

8. 世界杯直播频道 世界杯直播频道 FIFA 2026开球时间 National 世界杯直播频道 Human Genome Research Institute. Learning About Familial Hypercholesterolemia. http://www.genome.gov/25520184. 世界杯直播频道 FIFA 2026开球时间 2026世界杯直播赛程 Accessed 世界杯直播频道 FIFA 2026开球时间 FIFA 2026开球时间 July 2015.

9. Nordestgaard BG, Chapman MJ, Humphries 观看比赛直播 SE, et al. Familial Hypercholesterolaemia is Underdiagnosed and Undertreated in the General Population: Guidance FIFA 2026开球时间 for Clinicians to 世界杯直播频道 2026世界杯直播赛程 Prevent Coronary Heart Disease. 2026世界杯直播赛程 世界杯直播频道 Eur Heart J. 2013;34:3478-3490.

10. Sabatine MS, 世界杯直播频道 Giugliano RP, Wiviott SD, et al. Efficacy and Safety 世界杯直播频道 of Evolocumab in Reducing FIFA 2026开球时间 Lipids and Cardiovascular Events. FIFA 2026开球时间 N Engl J Med. 2026世界杯直播赛程 2015;372:1500-1509.

11. Koren MJ, Lundqvist P, Bolognese M, et al. Anti-PCSK9 monotherapy for FIFA 2026开球时间 hypercholesterolemia: the MENDEL-2 FIFA 2026开球时间 randomized, controlled phase III clinical trial of evolocumab. J Am Coll Cardiol. 2014;63:2531-2540.

12. Robinson JG, 世界杯直播频道 Nedergaard BS, Rogers WJ, et al. Effect of evolocumab or ezetimibe added to moderate or high-intensity statin therapy on LDL-C lowering in patients with hypercholesterolemia. The LAPLACE-2 世界杯直播频道 FIFA 2026开球时间 世界杯直播频道 观看比赛直播 randomized clinical trial. JAMA. 2014;311:1870-1882.

13. Raal FJ, Stein EA, Dufour FIFA 2026开球时间 R, et al. PCSK9 inhibition with evolocumab (AMG 145) in heterozygous familial hypercholesterolaemia (RUTHERFORD-2): a randomised, double-blind, placebo-controlled trial. Lancet. FIFA 2026开球时间 FIFA 2026开球时间 2026世界杯直播赛程 2015;385:331-340.

14. 世界杯直播频道 Stroes E, Colquhoun D, Sullivan D, et al. Anti-PCSK9 antibody effectively lowers cholesterol in patients with statin intolerance: the GAUSS-2 randomized, placebo-controlled phase 3 clinical trial of FIFA 2026开球时间 FIFA 2026开球时间 evolocumab. J Am Coll Cardiol. 2014;63:2541-2548.

15. Raal 世界杯直播频道 FJ, Honarpour N, Blom DJ, et al. Inhibition of PCSK9 with evolocumab in homozygous familial hypercholesterolaemia (TESLA Part 世界杯直播频道 B): a randomised, double-blind, placebo-controlled trial. Lancet. 2026世界杯直播赛程 2015;385:341-50.

16. Blom DJ, Hala T, Bolognese M. A 52-week 观看比赛直播 placebo-controlled trial of evolocumab in hyperlipidemia. N Engl J Med. 2014;370:1809-1819.

17. Koren MJ, Giugliano RP, Raal FJ, et 世界杯直播频道 al. Efficacy and Safety of 世界杯直播频道 观看比赛直播 Longer-Term 观看比赛直播 Administration of Evolocumab (AMG 145) in Patients With Hypercholesterolemia: 52-Week Results 观看比赛直播 from the Open-Label Study of Long-Term Evaluation Against LDL-C (OSLER) Randomized Trial. 2026世界杯直播赛程 FIFA 2026开球时间 世界杯直播频道 Circulation. 2014;129:234-243.

18. Lopez D. FIFA 2026开球时间 PCSK9: An enigmatic protease. Biochimica et Biophysica Acta. 2008;1781:184-191.

19. 世界杯直播频道 World Health Organization. Cardiovascular diseases (CVDs) fact sheet. http://www.who.int/mediacentre/factsheets/fs317/en/. 世界杯直播频道 Accessed 2026世界杯直播赛程 观看比赛直播 July 2015.